Characters that oppose the protagonist of a story or series. Said characters of this category may not necessarily be evil, just oppose the protagonist in their journey and prevent them from accomplishing their goal(s).
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A
- Abe no Seimei (Nue)
- Abigail (Bastard!!)
- Abo-Kado
- Absolute Will
- Abstract Entities (Marvel Comics)
- Abyss Mage
- Acnologia
- Adam (Tokyo Babel)
- Adam Taurus
- Adiane The Elegant
- Aeon
- Afro Droid
- Agent (The Matrix)
- Air Force One Angel
- Aka
- Akainu
- Akaza
- Aku
- Akuma (Street Fighter)
- Albion I
- Albion II
- Alcatraz
- Alcina Dimitrescu
-
- Aleister Crowley
- Alejandro
- Alexander Anderson
- Algol
- Algrim (Marvel Comics)
- Alice Twilight
- All For One
- Alpha Nanite
- Altair (Re:Creators)
- Alternates
- Alternative Weapon System (Bakugan)
- Ameyuri Ringo
- Ami
- Amon (Legend of Korra)
- Anastasia Blast
- Ancient King
- Android 17 (Toei)
- Animus (Fairy Tail)
- Anna Williams
-
- Anti-All (Marvel/616)
- Anti-God
- Anti-Spiral
- Anubis (Yu-Gi-Oh!)
- Ao Oni
- Ao Oni (Anime)
- Ao Oni (Composite)
- Aoi Yusaka
- Apophis
- Appule
- Aprile
- Arachne Gorgon
- Aratari
- Arba / Gyokuen
- Archer (EMIYA)
- Ardun
- Arlong
- Arpeggio
- Aruka Schild
- Ashes Blackburn
- Askin Nakk Le Vaar
- Asmodeus (SIN)
- Asriel Dreemurr
- Assassin (Hassan of the Cursed Arm)
- Assassin (Sasaki Kojirou)
- Astaroth (Bastard!!)
- Astaroth (Shinza Banshou)
- Astaroth (SIN)
- Asura (RAVE)
- Athena (The God of High School)
- Atros
- Augus
- Avaricious Vulcan
- Avdotya
- Axley Ivanovic
- Azazel (Tekken)
- Azenda The Tyrant
- Azhdaha
- Azula
B
- Babidi
- Baby Vegeta
- Bacchus Groh
- Bad Girl
- Bad Rap
- Bai Tza
- Bakugon
- Balgaras
- Ballos
- Balrog (Cave Story)
- Balrog (Street Fighter)
- Bambietta Basterbine
- Baragan Louisenbairn
- Baragon
- Barakidon
- Baran (Solo Leveling)
- Barem
- Baron Meinster
- Baruka
- Battra
- Bazz-B
- BB (Fate Series)
- Beast King
- Beatrice (Umineko no Naku Koro Ni)
- Beefcake
- Beelzebub (Bastard!!)
- Beelzebub (SIN)
- Beelzebub (The God of High School)
- Behemoth
- Belial (SIN)
- Belphegor (SIN)
- Berial
- Beringel
- Bernkastel
- Berserker (Heracles)
- Beru
- Beyond Birthday
- Beyonders (Marvel Comics)
- Biba Amatori
-
- Bill (Kill Bill)
- Bill Cipher
- Bilt (Bastard!!)
- Biollante
-
- Black Knight
-
- Blackhole Boy
- Blackwargreymon
- Blade Wolf
- Blueno
- Bojack
- Bon
- Bondrewd
- Boneless
- Borgoff Marcus
- Brandish μ
- Briar (Fairy Tail)
- Broly (BR/Canon)
- Broly (Toei)
- Bronco Mask
- Bungaku Banchou
- Burter
- Butler (Keyman: The Hand of Judgement)
- Buu
- Buyon
- Buzzard
- Byron
C
- Caesar Clown
- Caladbolg
- Camazotz (Monsterverse)
- Candice Catnipp
- Cao Cao (High School DxD)
- Caprico
- Captain Ginyu
- Carla Radames
- Carmilla (Bloodlust Movie)
- Carmilla (Castlevania)
- Carnage Kabuto
- Caster (Gilles de Rais)
- Caster (Medea)
- Cat Boy (Code: Breaker)
- Cell Jr.
- Cervantes de León
- Chakravartin
- Chandler
- Chaos (Sailor Moon)
- Charlotte Cracker
- Charlotte Katakuri
- Charlotte Smoothie
-
- Chi Long
- Chiyo (Toriko)
- Chris Walker
- Chrollo Lucifer
- Chthon (Marvel Comics)
- Chun-Woo Han
- Cinder Fall
- Claude Frollo
- Clear Note
- Clementine (Overlord)
- Cloe Walsh
- Cloud of Darkness
- Clover (Cloverfield)
-
- Commeson
- Cool Yankee (Code: Breaker)
- Cooler
- Cosmic Axis Amped Dormammu (Marvel Comics)
- Cosmina
- Count Magnus Lee
- Count Magnus Lee (1985 Movie)
- Coyote Starrk
- Crona